221774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2360272..2360794 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag LJF41_RS11795 Protein ID WP_000221344.1
Coordinates 2360272..2360556 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LJF41_RS11800 Protein ID WP_000885424.1
Coordinates 2360546..2360794 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS11770 (LJF41_11770) 2355276..2356517 - 1242 WP_001095723.1 MFS transporter -
LJF41_RS11775 (LJF41_11775) 2356507..2358015 - 1509 WP_000199421.1 FAD-dependent oxidoreductase -
LJF41_RS11780 (LJF41_11780) 2358060..2358548 + 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
LJF41_RS11785 (LJF41_11785) 2358741..2359820 + 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LJF41_RS11790 (LJF41_11790) 2359872..2360153 - 282 Protein_2284 RidA family protein -
LJF41_RS11795 (LJF41_11795) 2360272..2360556 - 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF41_RS11800 (LJF41_11800) 2360546..2360794 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF41_RS11805 (LJF41_11805) 2361094..2361552 + 459 WP_000381836.1 hypothetical protein -
LJF41_RS11810 (LJF41_11810) 2361546..2361878 + 333 WP_000253166.1 DUF1493 family protein -
LJF41_RS11815 (LJF41_11815) 2362042..2362992 + 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
LJF41_RS11820 (LJF41_11820) 2363063..2363638 - 576 Protein_2290 helix-turn-helix domain-containing protein -
LJF41_RS11825 (LJF41_11825) 2364053..2364976 - 924 WP_023230780.1 hypothetical protein -
LJF41_RS11830 (LJF41_11830) 2365410..2365625 - 216 WP_001530185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2358741..2367925 9184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T221774 WP_000221344.1 NZ_CP085811:c2360556-2360272 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T221774 NZ_CP117586:c2866835-2866680 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT221774 WP_000885424.1 NZ_CP085811:c2360794-2360546 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT221774 NZ_CP117586:2866847-2866905 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References