Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1300751..1301371 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF41_RS06295 Protein ID WP_001280991.1
Coordinates 1300751..1300969 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF41_RS06300 Protein ID WP_000344807.1
Coordinates 1300997..1301371 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS06255 (LJF41_06255) 1295974..1296543 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF41_RS06260 (LJF41_06260) 1296576..1296965 - 390 WP_000961285.1 MGMT family protein -
LJF41_RS06270 (LJF41_06270) 1297196..1298746 - 1551 WP_000213134.1 EAL domain-containing protein -
LJF41_RS06275 (LJF41_06275) 1298971..1299231 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF41_RS06280 (LJF41_06280) 1299237..1299377 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF41_RS06285 (LJF41_06285) 1299433..1299903 - 471 WP_000136183.1 YlaC family protein -
LJF41_RS06290 (LJF41_06290) 1300021..1300572 - 552 WP_001278791.1 maltose O-acetyltransferase -
LJF41_RS06295 (LJF41_06295) 1300751..1300969 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF41_RS06300 (LJF41_06300) 1300997..1301371 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF41_RS06305 (LJF41_06305) 1301867..1305016 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF41_RS06310 (LJF41_06310) 1305039..1306232 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221773 WP_001280991.1 NZ_CP085811:c1300969-1300751 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221773 NZ_CP117586:2522800-2523078 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221773 WP_000344807.1 NZ_CP085811:c1301371-1300997 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221773 NZ_CP117586:2523078-2523362 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References