Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 663257..663807 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF41_RS03365 Protein ID WP_001199743.1
Coordinates 663499..663807 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag LJF41_RS03360 Protein ID WP_000016243.1
Coordinates 663257..663496 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS03325 (LJF41_03325) 658525..659289 - 765 WP_000998688.1 gluconate 5-dehydrogenase -
LJF41_RS03330 (LJF41_03330) 659314..660345 - 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
LJF41_RS03335 (LJF41_03335) 660562..661092 + 531 WP_000896756.1 gluconokinase -
LJF41_RS03340 (LJF41_03340) 661120..662139 - 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
LJF41_RS03355 (LJF41_03355) 662924..663148 + 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
LJF41_RS03360 (LJF41_03360) 663257..663496 + 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF41_RS03365 (LJF41_03365) 663499..663807 + 309 WP_001199743.1 CcdB family protein Toxin
LJF41_RS03370 (LJF41_03370) 664229..664530 + 302 Protein_639 Arm DNA-binding domain-containing protein -
LJF41_RS03375 (LJF41_03375) 664892..668409 + 3518 Protein_640 AAA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 663257..678965 15708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221772 WP_001199743.1 NZ_CP085811:663499-663807 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221772 NZ_CP117586:2500254-2500640 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT221772 WP_000016243.1 NZ_CP085811:663257-663496 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT221772 NZ_CP117586:2500036-2500257 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References