Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 622657..623173 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LJF41_RS03150 Protein ID WP_000220578.1
Coordinates 622889..623173 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF41_RS03145 Protein ID WP_000212724.1
Coordinates 622657..622899 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS03125 (LJF41_03125) 617677..618810 + 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -
LJF41_RS03130 (LJF41_03130) 618794..619912 + 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF41_RS03135 (LJF41_03135) 619909..620649 + 741 WP_000779262.1 KDGP aldolase family protein -
LJF41_RS03140 (LJF41_03140) 620666..622579 + 1914 WP_001212145.1 BglG family transcription antiterminator -
LJF41_RS03145 (LJF41_03145) 622657..622899 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF41_RS03150 (LJF41_03150) 622889..623173 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF41_RS03155 (LJF41_03155) 623177..623641 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF41_RS03160 (LJF41_03160) 623858..625996 - 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
LJF41_RS03165 (LJF41_03165) 626405..628057 - 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T221771 WP_000220578.1 NZ_CP085811:622889-623173 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221771 NZ_CP117586:2435078-2435233 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGGCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221771 WP_000212724.1 NZ_CP085811:622657-622899 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221771 NZ_CP117586:c2435066-2435008 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References