Detailed information of TA system TA221770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 507759..508540
• Replicon: chromosome
• Accession: NZ_CP085811
• Organism: Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A752VN12
• Locus tag: LJF41_RS02525
• Protein ID: WP_000622305.1
• Coordinates: 508049..508540 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3V4SIN7
• Locus tag: LJF41_RS02520
• Protein ID: WP_001110453.1
• Coordinates: 507759..508052 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF41_RS02485 (LJF41_02485)	504059..504964	+	906	WP_001268205.1	YjiK family protein	-
LJF41_RS02490 (LJF41_02490)	505259..505393	-	135	Protein_469	hypothetical protein	-
LJF41_RS02495 (LJF41_02495)	505503..505602	-	100	Protein_470	hypothetical protein	-
LJF41_RS02500 (LJF41_02500)	505622..505804	+	183	WP_001527266.1	ATP-binding cassette domain-containing protein	-
LJF41_RS02505 (LJF41_02505)	505797..506084	-	288	WP_001269916.1	transcriptional regulator RtsB	-
LJF41_RS02510 (LJF41_02510)	506081..506956	-	876	WP_000921676.1	AraC family transcriptional regulator	-
LJF41_RS02515 (LJF41_02515)	507220..507442	-	223	Protein_474	hypothetical protein	-
LJF41_RS02520 (LJF41_02520)	507759..508052	+	294	WP_001110453.1	DUF1778 domain-containing protein	Antitoxin
LJF41_RS02525 (LJF41_02525)	508049..508540	+	492	WP_000622305.1	GNAT family N-acetyltransferase	Toxin
LJF41_RS02530 (LJF41_02530)	508775..509008	+	234	Protein_477	IS481 family transposase	-
LJF41_RS02535 (LJF41_02535)	509283..509510	-	228	WP_001112995.1	hypothetical protein	-
LJF41_RS02540 (LJF41_02540)	510099..510383	+	285	WP_192917775.1	PapB/FocB family fimbrial expression transcriptional regulator	-
LJF41_RS02545 (LJF41_02545)	510418..510957	+	540	WP_000721295.1	type 1 fimbrial protein	-
LJF41_RS02550 (LJF41_02550)	510967..513405	+	2439	WP_001014136.1	F4 (K88) fimbrial usher FaeD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeC / faeD / faeE / faeF / faeH / faeI	505797..521046	15249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17606.43 Da
• Isoelectric Point: 7.7297

>T221770 WP_000622305.1 NZ_CP085811:508049-508540 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T221770 NZ_CP117586:2121356-2121459 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10948.57 Da
• Isoelectric Point: 9.8590

>AT221770 WP_001110453.1 NZ_CP085811:507759-508052 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT221770 NZ_CP117586:c2121461-2121229 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: A0A752VN12

Antitoxin

• AlphaFold DB: A0A3V4SIN7