221767

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4357889..4358439 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF42_RS21620 Protein ID WP_001199743.1
Coordinates 4358131..4358439 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag LJF42_RS21615 Protein ID WP_000016243.1
Coordinates 4357889..4358128 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS21580 (LJF42_21580) 4353157..4353921 - 765 WP_000998688.1 gluconate 5-dehydrogenase -
LJF42_RS21585 (LJF42_21585) 4353946..4354977 - 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
LJF42_RS21590 (LJF42_21590) 4355194..4355724 + 531 WP_000896756.1 gluconokinase -
LJF42_RS21595 (LJF42_21595) 4355752..4356771 - 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
LJF42_RS21610 (LJF42_21610) 4357556..4357780 + 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
LJF42_RS21615 (LJF42_21615) 4357889..4358128 + 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF42_RS21620 (LJF42_21620) 4358131..4358439 + 309 WP_001199743.1 CcdB family protein Toxin
LJF42_RS21625 (LJF42_21625) 4358861..4359162 + 302 Protein_4206 Arm DNA-binding domain-containing protein -
LJF42_RS21630 (LJF42_21630) 4359524..4363040 + 3517 Protein_4207 AAA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221767 WP_001199743.1 NZ_CP085810:4358131-4358439 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221767 NZ_CP117586:636015-636329 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT221767 WP_000016243.1 NZ_CP085810:4357889-4358128 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT221767 NZ_CP117586:636326-636742 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References