221765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4202390..4203171 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag LJF42_RS20780 Protein ID WP_000622305.1
Coordinates 4202680..4203171 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag LJF42_RS20775 Protein ID WP_001110453.1
Coordinates 4202390..4202683 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS20740 (LJF42_20740) 4198690..4199595 + 906 WP_001268205.1 YjiK family protein -
LJF42_RS20745 (LJF42_20745) 4199890..4200024 - 135 Protein_4036 hypothetical protein -
LJF42_RS20750 (LJF42_20750) 4200134..4200233 - 100 Protein_4037 hypothetical protein -
LJF42_RS20755 (LJF42_20755) 4200253..4200435 + 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
LJF42_RS20760 (LJF42_20760) 4200428..4200715 - 288 WP_001269916.1 transcriptional regulator RtsB -
LJF42_RS20765 (LJF42_20765) 4200712..4201587 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF42_RS20770 (LJF42_20770) 4201851..4202073 - 223 Protein_4041 hypothetical protein -
LJF42_RS20775 (LJF42_20775) 4202390..4202683 + 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
LJF42_RS20780 (LJF42_20780) 4202680..4203171 + 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
LJF42_RS20785 (LJF42_20785) 4203406..4203639 + 234 Protein_4044 IS481 family transposase -
LJF42_RS20790 (LJF42_20790) 4203914..4204141 - 228 WP_001112995.1 hypothetical protein -
LJF42_RS20795 (LJF42_20795) 4204730..4205014 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
LJF42_RS20800 (LJF42_20800) 4205049..4205588 + 540 WP_000721295.1 type 1 fimbrial protein -
LJF42_RS20805 (LJF42_20805) 4205598..4208036 + 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 4200428..4215677 15249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T221765 WP_000622305.1 NZ_CP085810:4202680-4203171 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221765 NZ_CP117586:297993-298520 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT221765 WP_001110453.1 NZ_CP085810:4202390-4202683 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221765 NZ_CP117586:297720-297986 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References