Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3434507..3435267 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag LJF42_RS17040 Protein ID WP_000533907.1
Coordinates 3434507..3434992 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF42_RS17045 Protein ID WP_000965886.1
Coordinates 3434980..3435267 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS17010 (LJF42_17010) 3429570..3430232 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF42_RS17015 (LJF42_17015) 3430461..3431435 + 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF42_RS17020 (LJF42_17020) 3431485..3432195 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF42_RS17025 (LJF42_17025) 3432634..3432924 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF42_RS17030 (LJF42_17030) 3433212..3433424 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF42_RS17035 (LJF42_17035) 3433597..3434136 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
LJF42_RS17040 (LJF42_17040) 3434507..3434992 - 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
LJF42_RS17045 (LJF42_17045) 3434980..3435267 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF42_RS17050 (LJF42_17050) 3435445..3435912 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF42_RS17055 (LJF42_17055) 3436054..3436485 - 432 Protein_3325 IS3 family transposase -
LJF42_RS17060 (LJF42_17060) 3436747..3438816 - 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
LJF42_RS17065 (LJF42_17065) 3438826..3439737 - 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
LJF42_RS17070 (LJF42_17070) 3439876..3440178 - 303 WP_000605592.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T221762 WP_000533907.1 NZ_CP085810:c3434992-3434507 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221762 NZ_CP117584:5635-5940 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGTATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221762 WP_000965886.1 NZ_CP085810:c3435267-3434980 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221762 NZ_CP117584:5415-5633 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCTAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References