Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2827328..2827988 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF42_RS14085 Protein ID WP_000244756.1
Coordinates 2827328..2827741 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF42_RS14090 Protein ID WP_000351186.1
Coordinates 2827722..2827988 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS14065 (LJF42_14065) 2823269..2825002 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
LJF42_RS14070 (LJF42_14070) 2825008..2825721 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF42_RS14075 (LJF42_14075) 2825745..2826641 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF42_RS14080 (LJF42_14080) 2826754..2827275 + 522 WP_001055885.1 flavodoxin FldB -
LJF42_RS14085 (LJF42_14085) 2827328..2827741 - 414 WP_000244756.1 protein YgfX Toxin
LJF42_RS14090 (LJF42_14090) 2827722..2827988 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF42_RS14095 (LJF42_14095) 2828238..2829218 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
LJF42_RS14100 (LJF42_14100) 2829334..2829993 - 660 WP_000250289.1 hemolysin III family protein -
LJF42_RS14105 (LJF42_14105) 2830157..2830468 - 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
LJF42_RS14110 (LJF42_14110) 2830626..2832059 + 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221761 WP_000244756.1 NZ_CP085810:c2827741-2827328 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221761 NZ_CP117583:c4189131-4188913 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221761 WP_000351186.1 NZ_CP085810:c2827988-2827722 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221761 NZ_CP117583:c4189531-4189157 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References