Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-YafN |
| Location | 1305411..1305933 | Replicon | chromosome |
| Accession | NZ_CP085810 | ||
| Organism | Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A5J1ICX1 |
| Locus tag | LJF42_RS06695 | Protein ID | WP_000221344.1 |
| Coordinates | 1305411..1305695 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | V1H457 |
| Locus tag | LJF42_RS06700 | Protein ID | WP_000885424.1 |
| Coordinates | 1305685..1305933 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF42_RS06670 (LJF42_06670) | 1300415..1301656 | - | 1242 | WP_001095723.1 | MFS transporter | - |
| LJF42_RS06675 (LJF42_06675) | 1301646..1303154 | - | 1509 | WP_000199421.1 | FAD-dependent oxidoreductase | - |
| LJF42_RS06680 (LJF42_06680) | 1303199..1303687 | + | 489 | WP_001293633.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| LJF42_RS06685 (LJF42_06685) | 1303880..1304959 | + | 1080 | WP_000954705.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
| LJF42_RS06690 (LJF42_06690) | 1305011..1305292 | - | 282 | Protein_1301 | RidA family protein | - |
| LJF42_RS06695 (LJF42_06695) | 1305411..1305695 | - | 285 | WP_000221344.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJF42_RS06700 (LJF42_06700) | 1305685..1305933 | - | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LJF42_RS06705 (LJF42_06705) | 1306233..1306691 | + | 459 | WP_000381836.1 | hypothetical protein | - |
| LJF42_RS06710 (LJF42_06710) | 1306685..1307017 | + | 333 | WP_000253166.1 | DUF1493 family protein | - |
| LJF42_RS06715 (LJF42_06715) | 1307181..1308131 | + | 951 | WP_000941990.1 | toll/interleukin-1 receptor domain-containing protein | - |
| LJF42_RS06720 (LJF42_06720) | 1308202..1308777 | - | 576 | Protein_1307 | helix-turn-helix domain-containing protein | - |
| LJF42_RS06725 (LJF42_06725) | 1309192..1310115 | - | 924 | WP_023230780.1 | hypothetical protein | - |
| LJF42_RS06730 (LJF42_06730) | 1310549..1310764 | - | 216 | WP_001530185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1303880..1313064 | 9184 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11015.73 Da Isoelectric Point: 10.5388
>T221752 WP_000221344.1 NZ_CP085810:c1305695-1305411 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
Download Length: 285 bp
>T221752 NZ_CP117583:c2008284-2007880 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGTTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGTTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT221752 WP_000885424.1 NZ_CP085810:c1305933-1305685 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT221752 NZ_CP117583:c2008531-2008265 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1ICX1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I0WPN5 |