Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 245062..245682 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF42_RS01185 Protein ID WP_001280991.1
Coordinates 245062..245280 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF42_RS01190 Protein ID WP_000344807.1
Coordinates 245308..245682 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS01145 (LJF42_01145) 240285..240854 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF42_RS01150 (LJF42_01150) 240887..241276 - 390 WP_000961285.1 MGMT family protein -
LJF42_RS01160 (LJF42_01160) 241507..243057 - 1551 WP_000213134.1 EAL domain-containing protein -
LJF42_RS01165 (LJF42_01165) 243282..243542 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF42_RS01170 (LJF42_01170) 243548..243688 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF42_RS01175 (LJF42_01175) 243744..244214 - 471 WP_000136183.1 YlaC family protein -
LJF42_RS01180 (LJF42_01180) 244332..244883 - 552 WP_001278791.1 maltose O-acetyltransferase -
LJF42_RS01185 (LJF42_01185) 245062..245280 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF42_RS01190 (LJF42_01190) 245308..245682 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF42_RS01195 (LJF42_01195) 246178..249327 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF42_RS01200 (LJF42_01200) 249350..250543 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221751 WP_001280991.1 NZ_CP085810:c245280-245062 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221751 NZ_CP117583:c1854340-1854188 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221751 WP_000344807.1 NZ_CP085810:c245682-245308 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221751 NZ_CP117583:1854385-1854433 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References