Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4487067..4487827 Replicon chromosome
Accession NZ_CP085809
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag LJF43_RS22150 Protein ID WP_000533908.1
Coordinates 4487067..4487552 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag LJF43_RS22155 Protein ID WP_000965889.1
Coordinates 4487540..4487827 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF43_RS22120 (LJF43_22125) 4482137..4482799 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF43_RS22125 (LJF43_22130) 4483018..4483992 + 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF43_RS22130 (LJF43_22135) 4484042..4484752 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF43_RS22135 (LJF43_22140) 4485191..4485478 + 288 Protein_4325 HTH-type transcriptional regulator -
LJF43_RS22140 (LJF43_22145) 4485769..4485981 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF43_RS22145 (LJF43_22150) 4486157..4486696 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LJF43_RS22150 (LJF43_22155) 4487067..4487552 - 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
LJF43_RS22155 (LJF43_22160) 4487540..4487827 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
LJF43_RS22160 (LJF43_22165) 4488005..4488472 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF43_RS22165 (LJF43_22170) 4488614..4489042 - 429 Protein_4331 IS3 family transposase -
LJF43_RS22170 (LJF43_22175) 4489432..4491501 - 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
LJF43_RS22175 (LJF43_22180) 4491511..4492422 - 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T221750 WP_000533908.1 NZ_CP085809:c4487552-4487067 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221750 NZ_CP117583:c1814503-1814192 [Escherichia albertii]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT221750 WP_000965889.1 NZ_CP085809:c4487827-4487540 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221750 NZ_CP117583:c1814195-1813776 [Escherichia albertii]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References