Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3884699..3885347 Replicon chromosome
Accession NZ_CP085809
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag LJF43_RS19180 Protein ID WP_000244762.1
Coordinates 3884699..3885100 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF43_RS19185 Protein ID WP_000351186.1
Coordinates 3885081..3885347 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF43_RS19160 (LJF43_19165) 3880628..3882361 - 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -
LJF43_RS19165 (LJF43_19170) 3882367..3883080 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF43_RS19170 (LJF43_19175) 3883104..3884000 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF43_RS19175 (LJF43_19180) 3884113..3884634 + 522 WP_001055885.1 flavodoxin FldB -
LJF43_RS19180 (LJF43_19185) 3884699..3885100 - 402 WP_000244762.1 protein YgfX Toxin
LJF43_RS19185 (LJF43_19190) 3885081..3885347 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF43_RS19190 (LJF43_19195) 3885597..3886577 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
LJF43_RS19195 (LJF43_19200) 3886693..3887352 - 660 WP_000250289.1 hemolysin III family protein -
LJF43_RS19200 (LJF43_19205) 3887516..3887827 - 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
LJF43_RS19205 (LJF43_19210) 3887986..3889419 + 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T221749 WP_000244762.1 NZ_CP085809:c3885100-3884699 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

>T221749 NZ_CP117583:1754324-1754647 [Escherichia albertii]
ATTTTATCTGTACCGACCACGGTGCCAATTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAACATACCT
GCTGGAGCATCATTACGGCCTCACACTCAACGACACGCCATTCCACGACGACGCGGCTATCGAAGAACATATCGAGGCGG
GAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAGTACGAACTGGTTCGTATCGACCGAAAGGGATTTTCGTGG
CAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAACGTGAA
ATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221749 WP_000351186.1 NZ_CP085809:c3885347-3885081 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221749 NZ_CP117583:1753966-1754286 [Escherichia albertii]
ATGAAAAATTCATGGGGACTGAAGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCCGTCGTCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTGGATCAAGCATTTCCGCCAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTAAATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTTACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References