Detailed information of TA system TA221748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3867957..3868582
• Replicon: chromosome
• Accession: NZ_CP085809
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LJF43_RS19090
• Protein ID: WP_000911334.1
• Coordinates: 3867957..3868355 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M7S3S8
• Locus tag: LJF43_RS19095
• Protein ID: WP_000557549.1
• Coordinates: 3868355..3868582 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF43_RS19075 (LJF43_19080)	3864635..3865216	-	582	WP_001244646.1	fimbrial protein	-
LJF43_RS19080 (LJF43_19085)	3865935..3866567	-	633	WP_000835268.1	YfdX family protein	-
LJF43_RS19085 (LJF43_19090)	3866614..3867150	-	537	WP_001038500.1	STM3031 family outer membrane protein	-
LJF43_RS19090 (LJF43_19095)	3867957..3868355	-	399	WP_000911334.1	tRNA(fMet)-specific endonuclease VapC	Toxin
LJF43_RS19095 (LJF43_19100)	3868355..3868582	-	228	WP_000557549.1	toxin-antitoxin system antitoxin VapB	Antitoxin
LJF43_RS19100 (LJF43_19105)	3868759..3869010	+	252	WP_001540858.1	hypothetical protein	-
LJF43_RS19105 (LJF43_19110)	3869285..3870091	+	807	WP_227761088.1	DUF1460 domain-containing protein	-
LJF43_RS19110 (LJF43_19115)	3870724..3871845	-	1122	WP_000028980.1	hypothetical protein	-
LJF43_RS19115 (LJF43_19120)	3871947..3872402	-	456	WP_223229661.1	hypothetical protein	-
LJF43_RS19120 (LJF43_19125)	3872485..3872688	-	204	WP_000184036.1	hypothetical protein	-
LJF43_RS19125 (LJF43_19130)	3872692..3873411	-	720	WP_000082599.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3858767..3875663	16896

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15091.44 Da
• Isoelectric Point: 7.7785

>T221748 WP_000911334.1 NZ_CP085809:c3868355-3867957 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T221748 NZ_CP117583:c879046-878944 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8514.51 Da
• Isoelectric Point: 5.0210

>AT221748 WP_000557549.1 NZ_CP085809:c3868582-3868355 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT221748 NZ_CP117583:878942-879174 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Antitoxin

• PDB: 6IFM
• AlphaFold DB: A0A3V2Y5V5