Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3714209..3715023 Replicon chromosome
Accession NZ_CP085809
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF43_RS18375 Protein ID WP_000971655.1
Coordinates 3714496..3715023 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF43_RS18370 Protein ID WP_000855694.1
Coordinates 3714209..3714499 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF43_RS18350 (LJF43_18355) 3710101..3711789 - 1689 WP_000848103.1 type III secretion system outer membrane ring protein InvG -
LJF43_RS18355 (LJF43_18360) 3711786..3712436 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF43_RS18360 (LJF43_18365) 3712892..3713335 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF43_RS18365 (LJF43_18370) 3713739..3713939 + 201 Protein_3591 transposase -
LJF43_RS18370 (LJF43_18375) 3714209..3714499 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF43_RS18375 (LJF43_18380) 3714496..3715023 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF43_RS18380 (LJF43_18385) 3715096..3715517 - 422 Protein_3594 IS5/IS1182 family transposase -
LJF43_RS18385 (LJF43_18390) 3715744..3716400 + 657 WP_000420463.1 protein-serine/threonine phosphatase -
LJF43_RS18390 (LJF43_18395) 3716570..3717090 - 521 Protein_3596 cytoplasmic protein -
LJF43_RS18395 (LJF43_18400) 3717248..3719815 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3715096..3715242 146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221747 WP_000971655.1 NZ_CP085809:3714496-3715023 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221747 NZ_CP117583:c583814-583428 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTTATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221747 WP_000855694.1 NZ_CP085809:3714209-3714499 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221747 NZ_CP117583:c584032-583811 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References