Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3299727..3300347 Replicon chromosome
Accession NZ_CP085809
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF43_RS16345 Protein ID WP_001280991.1
Coordinates 3300129..3300347 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF43_RS16340 Protein ID WP_000344807.1
Coordinates 3299727..3300101 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF43_RS16330 (LJF43_16335) 3294866..3296059 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF43_RS16335 (LJF43_16340) 3296082..3299231 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
LJF43_RS16340 (LJF43_16345) 3299727..3300101 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF43_RS16345 (LJF43_16350) 3300129..3300347 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF43_RS16350 (LJF43_16355) 3300526..3301077 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF43_RS16355 (LJF43_16360) 3301195..3301665 + 471 WP_000136183.1 YlaC family protein -
LJF43_RS16360 (LJF43_16365) 3301721..3301861 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF43_RS16365 (LJF43_16370) 3301867..3302127 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF43_RS16370 (LJF43_16375) 3302352..3303902 + 1551 WP_000213129.1 EAL domain-containing protein -
LJF43_RS16380 (LJF43_16385) 3304133..3304522 + 390 WP_000961285.1 MGMT family protein -
LJF43_RS16385 (LJF43_16390) 3304555..3305124 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221746 WP_001280991.1 NZ_CP085809:3300129-3300347 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221746 NZ_CP117583:c561272-560994 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221746 WP_000344807.1 NZ_CP085809:3299727-3300101 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221746 NZ_CP117583:c560994-560710 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References