Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 675360..675876 Replicon chromosome
Accession NZ_CP085809
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LJF43_RS03390 Protein ID WP_000220578.1
Coordinates 675592..675876 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF43_RS03385 Protein ID WP_000212724.1
Coordinates 675360..675602 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF43_RS03365 (LJF43_03365) 670380..671513 + 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -
LJF43_RS03370 (LJF43_03370) 671497..672615 + 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF43_RS03375 (LJF43_03375) 672612..673352 + 741 WP_000779260.1 KDGP aldolase family protein -
LJF43_RS03380 (LJF43_03380) 673369..675282 + 1914 WP_001212152.1 BglG family transcription antiterminator -
LJF43_RS03385 (LJF43_03385) 675360..675602 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF43_RS03390 (LJF43_03390) 675592..675876 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF43_RS03395 (LJF43_03395) 675880..676344 - 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF43_RS03400 (LJF43_03400) 676465..678603 - 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
LJF43_RS03405 (LJF43_03405) 679012..680664 - 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T221736 WP_000220578.1 NZ_CP085809:675592-675876 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221736 NZ_CP117580:1091490-1091642 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221736 WP_000212724.1 NZ_CP085809:675360-675602 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221736 NZ_CP117580:c1091448-1091396 [Escherichia albertii]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References