Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4543762..4544522 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag LJF44_RS22380 Protein ID WP_000533908.1
Coordinates 4544037..4544522 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag LJF44_RS22375 Protein ID WP_000965889.1
Coordinates 4543762..4544049 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS22355 (LJF44_22360) 4539167..4540078 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
LJF44_RS22360 (LJF44_22365) 4540088..4542157 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
LJF44_RS22365 (LJF44_22370) 4542547..4542975 + 429 Protein_4361 IS3 family transposase -
LJF44_RS22370 (LJF44_22375) 4543117..4543584 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF44_RS22375 (LJF44_22380) 4543762..4544049 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
LJF44_RS22380 (LJF44_22385) 4544037..4544522 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
LJF44_RS22385 (LJF44_22390) 4544893..4545432 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LJF44_RS22390 (LJF44_22395) 4545608..4545820 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF44_RS22395 (LJF44_22400) 4546111..4546398 - 288 Protein_4367 HTH-type transcriptional regulator -
LJF44_RS22400 (LJF44_22405) 4546837..4547547 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF44_RS22405 (LJF44_22410) 4547597..4548571 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF44_RS22410 (LJF44_22415) 4548790..4549452 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T221731 WP_000533908.1 NZ_CP085808:4544037-4544522 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221731 NZ_CP117576:c89891-89406 [Escherichia albertii]
ATGGGATGTGTAACAGCACCAGAACCGTTATCCTCATTTCATCAGGCAGCTGAATTTGTCAGTGGTGAAGTTGTGCTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAGGTACTCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACAC
AACAAATAGTCGGTTTTTACTCACTGGTCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATACCTGTCATTATACTTGCACGCCTGGCTGTTGATGTGTCATTCCGTGGAAAAGGGCTTGGCGCGGACTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCACTTACGG
AAAGCGCAAAACAGTTTTATATTCATCATGGCCTTACGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT221731 WP_000965889.1 NZ_CP085808:4543762-4544049 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221731 NZ_CP117576:c90163-89879 [Escherichia albertii]
ATGATATACGGAGGCTTTATGAAATCAGGGGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATAC
CGCTGCAGAAATTCTTCATAAGTCACGTACAGACTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAAGCAATATGAAGAGTTCATCGAAATGCTTGATGCCCCAGTTGCAGATGAACCT
GCCATTGAAAAATTGTTGGTAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References