Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2412095..2412624 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MRA_RS11355 Protein ID WP_003411124.1
Coordinates 2412095..2412412 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MRA_RS11360 Protein ID WP_003411127.1
Coordinates 2412409..2412624 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS11325 2407232..2408308 + 1077 WP_003411110.1 hypothetical protein -
MRA_RS11330 2408305..2408586 + 282 WP_003411112.1 hypothetical protein -
MRA_RS11335 2408622..2409695 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
MRA_RS11340 2409700..2410230 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MRA_RS11345 2410278..2411624 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MRA_RS11355 2412095..2412412 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRA_RS11360 2412409..2412624 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MRA_RS11365 2412879..2413937 + 1059 WP_003411129.1 hypothetical protein -
MRA_RS11370 2414067..2414423 - 357 WP_003411130.1 hypothetical protein -
MRA_RS11375 2414518..2415300 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MRA_RS11380 2415568..2415858 - 291 WP_003900476.1 YggT family protein -
MRA_RS11385 2416020..2416676 - 657 WP_003411133.1 cell division protein SepF -
MRA_RS11390 2416742..2417518 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T22173 WP_003411124.1 NC_009525:c2412412-2412095 [Mycobacterium tuberculosis H37Ra]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T22173 NC_009525:c2412412-2412095 [Mycobacterium tuberculosis H37Ra]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT22173 WP_003411127.1 NC_009525:c2412624-2412409 [Mycobacterium tuberculosis H37Ra]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT22173 NC_009525:c2412624-2412409 [Mycobacterium tuberculosis H37Ra]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References