Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3806439..3807220 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag LJF44_RS18920 Protein ID WP_000626103.1
Coordinates 3806439..3806930 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag LJF44_RS18925 Protein ID WP_001110456.1
Coordinates 3806927..3807220 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS18895 (LJF44_18900) 3802206..3803570 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
LJF44_RS18900 (LJF44_18905) 3803567..3804601 - 1035 WP_001195363.1 ParA family protein -
LJF44_RS18905 (LJF44_18910) 3804815..3804889 - 75 Protein_3696 helix-turn-helix domain-containing protein -
LJF44_RS18910 (LJF44_18915) 3805269..3805346 + 78 Protein_3697 porin family protein -
LJF44_RS18915 (LJF44_18920) 3805446..3806198 + 753 WP_001785756.1 non-specific acid phosphatase -
LJF44_RS18920 (LJF44_18925) 3806439..3806930 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
LJF44_RS18925 (LJF44_18930) 3806927..3807220 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
LJF44_RS18930 (LJF44_18935) 3807537..3807759 + 223 Protein_3701 hypothetical protein -
LJF44_RS18935 (LJF44_18940) 3808025..3808900 + 876 WP_000921674.1 AraC family transcriptional regulator -
LJF44_RS18940 (LJF44_18945) 3808897..3809184 + 288 WP_001269916.1 transcriptional regulator RtsB -
LJF44_RS18945 (LJF44_18950) 3809207..3809423 + 217 Protein_3704 hypothetical protein -
LJF44_RS18950 (LJF44_18955) 3809431..3809775 + 345 WP_100680417.1 Ig-like domain-containing protein -
LJF44_RS18955 (LJF44_18960) 3810062..3810967 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T221728 WP_000626103.1 NZ_CP085808:c3806930-3806439 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221728 NZ_CP117575:c4311605-4311387 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT221728 WP_001110456.1 NZ_CP085808:c3807220-3806927 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221728 NZ_CP117575:c4312005-4311631 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGTCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References