Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3682713..3683491 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag LJF44_RS18200 Protein ID WP_000622308.1
Coordinates 3682713..3683201 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag LJF44_RS18205 Protein ID WP_001143724.1
Coordinates 3683198..3683491 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS18185 (LJF44_18190) 3679159..3681444 + 2286 WP_010989300.1 hypothetical protein -
LJF44_RS18190 (LJF44_18195) 3681748..3681999 + 252 WP_024131240.1 hypothetical protein -
LJF44_RS18195 (LJF44_18200) 3682081..3682533 + 453 WP_000434168.1 hypothetical protein -
LJF44_RS18200 (LJF44_18205) 3682713..3683201 - 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
LJF44_RS18205 (LJF44_18210) 3683198..3683491 - 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
LJF44_RS18210 (LJF44_18215) 3683918..3684931 - 1014 WP_000449622.1 site-specific integrase -
LJF44_RS18215 (LJF44_18220) 3685095..3686684 - 1590 WP_000488995.1 TraI domain-containing protein -
LJF44_RS18220 (LJF44_18225) 3686668..3688179 - 1512 WP_001120833.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 3670496..3804736 134240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T221727 WP_000622308.1 NZ_CP085808:c3683201-3682713 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T221727 NZ_CP117575:c3857981-3857829 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT221727 WP_001143724.1 NZ_CP085808:c3683491-3683198 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221727 NZ_CP117575:3858030-3858087 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References