Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3565593..3566109 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LJF44_RS17580 Protein ID WP_000220578.1
Coordinates 3565593..3565877 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF44_RS17585 Protein ID WP_000212724.1
Coordinates 3565867..3566109 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS17565 (LJF44_17570) 3560805..3562457 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
LJF44_RS17570 (LJF44_17575) 3562866..3565004 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
LJF44_RS17575 (LJF44_17580) 3565125..3565589 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF44_RS17580 (LJF44_17585) 3565593..3565877 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF44_RS17585 (LJF44_17590) 3565867..3566109 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF44_RS17590 (LJF44_17595) 3566187..3568100 - 1914 WP_001212152.1 BglG family transcription antiterminator -
LJF44_RS17595 (LJF44_17600) 3568117..3568857 - 741 WP_000779260.1 KDGP aldolase family protein -
LJF44_RS17600 (LJF44_17605) 3568854..3569972 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF44_RS17605 (LJF44_17610) 3569956..3571089 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T221726 WP_000220578.1 NZ_CP085808:c3565877-3565593 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221726 NZ_CP117575:3715353-3715730 [Escherichia albertii]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCTCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCAC
TCGTCTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGCAATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCCGGGTTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATAGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGAGAAACGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221726 WP_000212724.1 NZ_CP085808:c3566109-3565867 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221726 NZ_CP117575:3714898-3715263 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACTCATCCCAATGACAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACACC
CTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAA
CTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References