Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3461749..3462325 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF44_RS17105 Protein ID WP_001131963.1
Coordinates 3462038..3462325 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF44_RS17100 Protein ID WP_000063142.1
Coordinates 3461749..3462051 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS17085 (LJF44_17090) 3458259..3460409 + 2151 WP_000379910.1 pyruvate/proton symporter BtsT -
LJF44_RS17090 (LJF44_17095) 3460504..3460707 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF44_RS17095 (LJF44_17100) 3460718..3461674 + 957 WP_000187846.1 GTPase -
LJF44_RS17100 (LJF44_17105) 3461749..3462051 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF44_RS17105 (LJF44_17110) 3462038..3462325 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF44_RS17110 (LJF44_17115) 3462578..3463492 - 915 WP_000290515.1 restriction endonuclease -
LJF44_RS17115 (LJF44_17120) 3463690..3467199 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221725 WP_001131963.1 NZ_CP085808:c3462325-3462038 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221725 NZ_CP117575:3693610-3693783 [Escherichia albertii]
ATAGCACTATTCTCTAAAATATTAAATTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTAGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221725 WP_000063142.1 NZ_CP085808:c3462051-3461749 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221725 NZ_CP117575:3693286-3693582 [Escherichia albertii]
ATGAAATATAAAAATAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTGTGATATGAATTTTTCATCTGTAGTGGCTGATGAATATGTGATACCACGACAATTGAATGAAAATT
CTTTAGCAATCACAACATCACTCTCCACAAGTAAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGATAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References