Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 940926..941546 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF44_RS04615 Protein ID WP_001280991.1
Coordinates 940926..941144 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF44_RS04620 Protein ID WP_000344807.1
Coordinates 941172..941546 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS04575 (LJF44_04575) 936149..936718 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF44_RS04580 (LJF44_04580) 936751..937140 - 390 WP_000961285.1 MGMT family protein -
LJF44_RS04590 (LJF44_04590) 937371..938921 - 1551 WP_000213129.1 EAL domain-containing protein -
LJF44_RS04595 (LJF44_04595) 939146..939406 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF44_RS04600 (LJF44_04600) 939412..939552 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF44_RS04605 (LJF44_04605) 939608..940078 - 471 WP_000136183.1 YlaC family protein -
LJF44_RS04610 (LJF44_04610) 940196..940747 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF44_RS04615 (LJF44_04615) 940926..941144 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF44_RS04620 (LJF44_04620) 941172..941546 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF44_RS04625 (LJF44_04625) 942042..945191 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
LJF44_RS04630 (LJF44_04630) 945214..946407 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221716 WP_001280991.1 NZ_CP085808:c941144-940926 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221716 NZ_CP117575:c1885516-1885364 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221716 WP_000344807.1 NZ_CP085808:c941546-941172 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221716 NZ_CP117575:1885558-1885610 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References