Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 526259..527073 Replicon chromosome
Accession NZ_CP085808
Organism Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF44_RS02585 Protein ID WP_000971655.1
Coordinates 526259..526786 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF44_RS02590 Protein ID WP_000855694.1
Coordinates 526783..527073 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF44_RS02565 (LJF44_02565) 521467..524034 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
LJF44_RS02570 (LJF44_02570) 524192..524712 + 521 Protein_495 cytoplasmic protein -
LJF44_RS02575 (LJF44_02575) 524882..525538 - 657 WP_000420463.1 protein-serine/threonine phosphatase -
LJF44_RS02580 (LJF44_02580) 525765..526186 + 422 Protein_497 IS5/IS1182 family transposase -
LJF44_RS02585 (LJF44_02585) 526259..526786 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF44_RS02590 (LJF44_02590) 526783..527073 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF44_RS02595 (LJF44_02595) 527343..527543 - 201 Protein_500 transposase -
LJF44_RS02600 (LJF44_02600) 527947..528390 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF44_RS02605 (LJF44_02605) 528846..529496 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF44_RS02610 (LJF44_02610) 529493..531181 + 1689 WP_000848103.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 526040..526186 146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221715 WP_000971655.1 NZ_CP085808:c526786-526259 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221715 NZ_CP117575:c1089078-1088923 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221715 WP_000855694.1 NZ_CP085808:c527073-526783 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221715 NZ_CP117575:1089090-1089148 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References