Detailed information of TA system TA221714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 372714..373339
• Replicon: chromosome
• Accession: NZ_CP085808
• Organism: Salmonella enterica subsp. enterica serovar Typhi strain Entei

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LJF44_RS01870
• Protein ID: WP_000911334.1
• Coordinates: 372941..373339 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M7S3S8
• Locus tag: LJF44_RS01865
• Protein ID: WP_000557549.1
• Coordinates: 372714..372941 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF44_RS01835 (LJF44_01835)	367885..368604	+	720	WP_000082599.1	Rha family transcriptional regulator	-
LJF44_RS01840 (LJF44_01840)	368608..368811	+	204	WP_000184036.1	hypothetical protein	-
LJF44_RS01845 (LJF44_01845)	368894..369349	+	456	WP_223229661.1	hypothetical protein	-
LJF44_RS01850 (LJF44_01850)	369451..370572	+	1122	WP_000028980.1	hypothetical protein	-
LJF44_RS01855 (LJF44_01855)	371205..372011	-	807	WP_227761088.1	DUF1460 domain-containing protein	-
LJF44_RS01860 (LJF44_01860)	372286..372537	-	252	WP_001540858.1	hypothetical protein	-
LJF44_RS01865 (LJF44_01865)	372714..372941	+	228	WP_000557549.1	toxin-antitoxin system antitoxin VapB	Antitoxin
LJF44_RS01870 (LJF44_01870)	372941..373339	+	399	WP_000911334.1	tRNA(fMet)-specific endonuclease VapC	Toxin
LJF44_RS01875 (LJF44_01875)	374146..374682	+	537	WP_001038500.1	STM3031 family outer membrane protein	-
LJF44_RS01880 (LJF44_01880)	374729..375361	+	633	WP_000835268.1	YfdX family protein	-
LJF44_RS01885 (LJF44_01885)	376080..376661	+	582	WP_001244646.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	365633..381784	16151

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15091.44 Da
• Isoelectric Point: 7.7785

>T221714 WP_000911334.1 NZ_CP085808:372941-373339 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T221714 NZ_CP117575:c910199-910096 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8514.51 Da
• Isoelectric Point: 5.0210

>AT221714 WP_000557549.1 NZ_CP085808:372714-372941 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT221714 NZ_CP117575:910094-910326 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Antitoxin

• PDB: 6IFM
• AlphaFold DB: A0A3V2Y5V5