Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4751041..4751657 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag LJF45_RS23375 Protein ID WP_000238494.1
Coordinates 4751041..4751415 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag LJF45_RS23380 Protein ID WP_001523745.1
Coordinates 4751415..4751657 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS23360 (LJF45_23365) 4748543..4749445 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
LJF45_RS23365 (LJF45_23370) 4749442..4750077 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF45_RS23370 (LJF45_23375) 4750074..4751003 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
LJF45_RS23375 (LJF45_23380) 4751041..4751415 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
LJF45_RS23380 (LJF45_23385) 4751415..4751657 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
LJF45_RS23385 (LJF45_23390) 4751862..4752791 + 930 WP_001162859.1 alpha/beta hydrolase -
LJF45_RS23390 (LJF45_23395) 4752877..4753188 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
LJF45_RS23395 (LJF45_23400) 4753185..4753631 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF45_RS23400 (LJF45_23405) 4753646..4754587 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF45_RS23405 (LJF45_23410) 4754632..4755069 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
LJF45_RS23410 (LJF45_23415) 4755066..4755938 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF45_RS23415 (LJF45_23420) 4755932..4756531 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T221711 WP_000238494.1 NZ_CP085807:c4751415-4751041 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

>T221711 NZ_CP117575:381615-381770 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGGCGGCGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGACAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT221711 WP_001523745.1 NZ_CP085807:c4751657-4751415 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT221711 NZ_CP117575:c381603-381545 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References