Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4362174..4362955 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag LJF45_RS21565 Protein ID WP_000626103.1
Coordinates 4362174..4362665 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag LJF45_RS21570 Protein ID WP_001110456.1
Coordinates 4362662..4362955 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS21540 (LJF45_21545) 4357941..4359305 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
LJF45_RS21545 (LJF45_21550) 4359302..4360336 - 1035 WP_001195363.1 ParA family protein -
LJF45_RS21550 (LJF45_21555) 4360550..4360624 - 75 Protein_4210 helix-turn-helix domain-containing protein -
LJF45_RS21555 (LJF45_21560) 4361004..4361081 + 78 Protein_4211 porin family protein -
LJF45_RS21560 (LJF45_21565) 4361181..4361933 + 753 WP_001785756.1 non-specific acid phosphatase -
LJF45_RS21565 (LJF45_21570) 4362174..4362665 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
LJF45_RS21570 (LJF45_21575) 4362662..4362955 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
LJF45_RS21575 (LJF45_21580) 4363272..4363494 + 223 Protein_4215 hypothetical protein -
LJF45_RS21580 (LJF45_21585) 4363760..4364635 + 876 WP_000921674.1 AraC family transcriptional regulator -
LJF45_RS21585 (LJF45_21590) 4364632..4364919 + 288 WP_001269916.1 transcriptional regulator RtsB -
LJF45_RS21590 (LJF45_21595) 4364942..4365158 + 217 Protein_4218 hypothetical protein -
LJF45_RS21595 (LJF45_21600) 4365166..4365510 + 345 WP_100680417.1 Ig-like domain-containing protein -
LJF45_RS21600 (LJF45_21605) 4365797..4366702 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T221710 WP_000626103.1 NZ_CP085807:c4362665-4362174 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221710 NZ_CP117572:23201-23581 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCAGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT221710 WP_001110456.1 NZ_CP085807:c4362955-4362662 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221710 NZ_CP117572:22980-23201 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References