Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4238448..4239226 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag LJF45_RS20845 Protein ID WP_000622308.1
Coordinates 4238448..4238936 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag LJF45_RS20850 Protein ID WP_001143724.1
Coordinates 4238933..4239226 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS20830 (LJF45_20835) 4234894..4237179 + 2286 WP_010989300.1 hypothetical protein -
LJF45_RS20835 (LJF45_20840) 4237483..4237734 + 252 WP_024131240.1 hypothetical protein -
LJF45_RS20840 (LJF45_20845) 4237816..4238268 + 453 WP_000434168.1 hypothetical protein -
LJF45_RS20845 (LJF45_20850) 4238448..4238936 - 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
LJF45_RS20850 (LJF45_20855) 4238933..4239226 - 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
LJF45_RS20855 (LJF45_20860) 4239653..4240666 - 1014 WP_000449622.1 site-specific integrase -
LJF45_RS20860 (LJF45_20865) 4240830..4242419 - 1590 WP_000488995.1 TraI domain-containing protein -
LJF45_RS20865 (LJF45_20870) 4242403..4243914 - 1512 WP_001120833.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 4226231..4360471 134240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T221709 WP_000622308.1 NZ_CP085807:c4238936-4238448 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T221709 NZ_CP117571:149515-149796 [Escherichia albertii]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAAGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGTCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGATTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGCGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT221709 WP_001143724.1 NZ_CP085807:c4239226-4238933 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221709 NZ_CP117571:149274-149525 [Escherichia albertii]
ATGAGTTATCAAATCCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCGATGGGAACCGTAGCTGAAGG
TGAAGGGGGCGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAGCCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References