Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4017484..4018060 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF45_RS19750 Protein ID WP_001131963.1
Coordinates 4017773..4018060 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF45_RS19745 Protein ID WP_000063142.1
Coordinates 4017484..4017786 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS19730 (LJF45_19735) 4013994..4016144 + 2151 WP_000379910.1 pyruvate/proton symporter BtsT -
LJF45_RS19735 (LJF45_19740) 4016239..4016442 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF45_RS19740 (LJF45_19745) 4016453..4017409 + 957 WP_000187846.1 GTPase -
LJF45_RS19745 (LJF45_19750) 4017484..4017786 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF45_RS19750 (LJF45_19755) 4017773..4018060 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF45_RS19755 (LJF45_19760) 4018313..4019227 - 915 WP_000290515.1 restriction endonuclease -
LJF45_RS19760 (LJF45_19765) 4019425..4022934 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221707 WP_001131963.1 NZ_CP085807:c4018060-4017773 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221707 NZ_CP117571:c54462-54313 [Escherichia albertii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221707 WP_000063142.1 NZ_CP085807:c4017786-4017484 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221707 NZ_CP117571:54506-54567 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References