Detailed information of TA system TA221698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1495340..1495960
• Replicon: chromosome
• Accession: NZ_CP085807
• Organism: Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF45_RS07255
• Protein ID: WP_001280991.1
• Coordinates: 1495340..1495558 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJF45_RS07260
• Protein ID: WP_000344807.1
• Coordinates: 1495586..1495960 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF45_RS07215 (LJF45_07215)	1490563..1491132	+	570	WP_000779802.1	YbaY family lipoprotein	-
LJF45_RS07220 (LJF45_07220)	1491165..1491554	-	390	WP_000961285.1	MGMT family protein	-
LJF45_RS07230 (LJF45_07230)	1491785..1493335	-	1551	WP_000213129.1	EAL domain-containing protein	-
LJF45_RS07235 (LJF45_07235)	1493560..1493820	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF45_RS07240 (LJF45_07240)	1493826..1493966	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF45_RS07245 (LJF45_07245)	1494022..1494492	-	471	WP_000136183.1	YlaC family protein	-
LJF45_RS07250 (LJF45_07250)	1494610..1495161	-	552	WP_001278793.1	maltose O-acetyltransferase	-
LJF45_RS07255 (LJF45_07255)	1495340..1495558	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF45_RS07260 (LJF45_07260)	1495586..1495960	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJF45_RS07265 (LJF45_07265)	1496456..1499605	-	3150	WP_001132507.1	efflux RND transporter permease AcrB	-
LJF45_RS07270 (LJF45_07270)	1499628..1500821	-	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221698 WP_001280991.1 NZ_CP085807:c1495558-1495340 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221698 NZ_CP117570:906921-907325 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGTTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221698 WP_000344807.1 NZ_CP085807:c1495960-1495586 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221698 NZ_CP117570:906674-906940 [Escherichia albertii]
ATGGACATTAACAATAAAGCTCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAGTGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0