Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 927128..927753 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LJF45_RS04510 Protein ID WP_000911334.1
Coordinates 927355..927753 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF45_RS04505 Protein ID WP_000557549.1
Coordinates 927128..927355 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS04475 (LJF45_04475) 922299..923018 + 720 WP_000082599.1 Rha family transcriptional regulator -
LJF45_RS04480 (LJF45_04480) 923022..923225 + 204 WP_000184036.1 hypothetical protein -
LJF45_RS04485 (LJF45_04485) 923308..923763 + 456 WP_223229661.1 hypothetical protein -
LJF45_RS04490 (LJF45_04490) 923865..924986 + 1122 WP_000028980.1 hypothetical protein -
LJF45_RS04495 (LJF45_04495) 925619..926425 - 807 WP_227761088.1 DUF1460 domain-containing protein -
LJF45_RS04500 (LJF45_04500) 926700..926951 - 252 WP_001540858.1 hypothetical protein -
LJF45_RS04505 (LJF45_04505) 927128..927355 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF45_RS04510 (LJF45_04510) 927355..927753 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF45_RS04515 (LJF45_04515) 928560..929096 + 537 WP_001038500.1 STM3031 family outer membrane protein -
LJF45_RS04520 (LJF45_04520) 929143..929775 + 633 WP_000835268.1 YfdX family protein -
LJF45_RS04525 (LJF45_04525) 930494..931075 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 920047..936198 16151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T221696 WP_000911334.1 NZ_CP085807:927355-927753 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221696 NZ_CP117570:162444-162596 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221696 WP_000557549.1 NZ_CP085807:927128-927355 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221696 NZ_CP117570:c162393-162339 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References