Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 910363..911011 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag LJF45_RS04420 Protein ID WP_000244762.1
Coordinates 910610..911011 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF45_RS04415 Protein ID WP_000351186.1
Coordinates 910363..910629 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS04395 (LJF45_04395) 906291..907724 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
LJF45_RS04400 (LJF45_04400) 907883..908194 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
LJF45_RS04405 (LJF45_04405) 908358..909017 + 660 WP_000250289.1 hemolysin III family protein -
LJF45_RS04410 (LJF45_04410) 909133..910113 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
LJF45_RS04415 (LJF45_04415) 910363..910629 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF45_RS04420 (LJF45_04420) 910610..911011 + 402 WP_000244762.1 protein YgfX Toxin
LJF45_RS04425 (LJF45_04425) 911076..911597 - 522 WP_001055885.1 flavodoxin FldB -
LJF45_RS04430 (LJF45_04430) 911710..912606 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF45_RS04435 (LJF45_04435) 912630..913343 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF45_RS04440 (LJF45_04440) 913349..915082 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T221695 WP_000244762.1 NZ_CP085807:910610-911011 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

>T221695 NZ_CP117569:5635-5940 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGTATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221695 WP_000351186.1 NZ_CP085807:910363-910629 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221695 NZ_CP117569:5415-5633 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCTAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References