Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 307773..308533 Replicon chromosome
Accession NZ_CP085807
Organism Salmonella enterica subsp. enterica serovar Typhi strain Suicune

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag LJF45_RS01450 Protein ID WP_000533908.1
Coordinates 308048..308533 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag LJF45_RS01445 Protein ID WP_000965889.1
Coordinates 307773..308060 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF45_RS01425 (LJF45_01425) 303178..304089 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
LJF45_RS01430 (LJF45_01430) 304099..306168 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
LJF45_RS01435 (LJF45_01435) 306558..306986 + 429 Protein_273 IS3 family transposase -
LJF45_RS01440 (LJF45_01440) 307128..307595 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF45_RS01445 (LJF45_01445) 307773..308060 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
LJF45_RS01450 (LJF45_01450) 308048..308533 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
LJF45_RS01455 (LJF45_01455) 308904..309443 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LJF45_RS01460 (LJF45_01460) 309619..309831 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF45_RS01465 (LJF45_01465) 310122..310409 - 288 Protein_279 HTH-type transcriptional regulator -
LJF45_RS01470 (LJF45_01470) 310848..311558 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF45_RS01475 (LJF45_01475) 311608..312582 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF45_RS01480 (LJF45_01480) 312801..313463 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T221694 WP_000533908.1 NZ_CP085807:308048-308533 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221694 NZ_CP117568:c4193979-4193761 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT221694 WP_000965889.1 NZ_CP085807:307773-308060 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221694 NZ_CP117568:c4194379-4194005 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References