Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4209145..4209905 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF46_RS20595 Protein ID WP_000533912.1
Coordinates 4209145..4209630 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF46_RS20600 Protein ID WP_000965886.1
Coordinates 4209618..4209905 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS20565 (4204217) 4204217..4204879 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF46_RS20570 (4205098) 4205098..4206072 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF46_RS20575 (4206122) 4206122..4206832 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF46_RS20580 (4207271) 4207271..4207561 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF46_RS20585 (4207849) 4207849..4208061 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF46_RS20590 (4208235) 4208235..4208774 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF46_RS20595 (4209145) 4209145..4209630 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF46_RS20600 (4209618) 4209618..4209905 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF46_RS20605 (4210083) 4210083..4210550 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF46_RS20610 (4210722) 4210722..4211120 - 399 Protein_4014 IS3 family transposase -
LJF46_RS20615 (4211510) 4211510..4213579 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF46_RS20620 (4213589) 4213589..4214500 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221691 WP_000533912.1 NZ_CP085806:c4209630-4209145 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221691 NZ_CP117568:3616850-3617191 [Escherichia albertii]
ATGAAAATTATACCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ATGCCGGAATCACTTTGGTTGATGCCATCAATTTTTTGGTGGAGAAGTACCAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTACGGGCGCGGCAGGCTACAGGTCTGCTGCGCCGCTG
CCATAACACGGCGACACGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221691 WP_000965886.1 NZ_CP085806:c4209905-4209618 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221691 NZ_CP117568:3616484-3616819 [Escherichia albertii]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTTACACCACGCTTCACTGCACGACTGGT
ACAGGAAAGACATAACCTGAATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTCCCGGTGCTGATGAAACAACGGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTACACGCCAAAGGGCTGACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCATTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References