Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4099190..4099776 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag LJF46_RS20110 Protein ID WP_000174964.1
Coordinates 4099190..4099558 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag LJF46_RS20115 Protein ID WP_001522145.1
Coordinates 4099555..4099776 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS20090 (4094709) 4094709..4095779 - 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
LJF46_RS20095 (4095781) 4095781..4096626 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LJF46_RS20100 (4096623) 4096623..4097510 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LJF46_RS20105 (4097615) 4097615..4098931 - 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJF46_RS20110 (4099190) 4099190..4099558 - 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF46_RS20115 (4099555) 4099555..4099776 - 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF46_RS20120 (4099907) 4099907..4100620 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LJF46_RS20125 (4100622) 4100622..4101389 - 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LJF46_RS20130 (4101386) 4101386..4102663 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
LJF46_RS20135 (4102660) 4102660..4103586 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LJF46_RS20140 (4103646) 4103646..4104755 - 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4093972..4109996 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T221690 WP_000174964.1 NZ_CP085806:c4099558-4099190 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T221690 NZ_CP117568:c2736705-2736553 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT221690 WP_001522145.1 NZ_CP085806:c4099776-4099555 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT221690 NZ_CP117568:2736756-2736810 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4

Antitoxin

Source ID Structure

References