Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 344526..345076 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF46_RS01635 Protein ID WP_001199743.1
Coordinates 344768..345076 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF46_RS01630 Protein ID WP_001118105.1
Coordinates 344526..344765 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS01595 (339965) 339965..340996 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF46_RS01600 (341213) 341213..341743 + 531 WP_000896758.1 gluconokinase -
LJF46_RS01605 (341771) 341771..342790 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF46_RS01620 (343547) 343547..344092 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF46_RS01625 (344169) 344169..344417 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF46_RS01630 (344526) 344526..344765 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF46_RS01635 (344768) 344768..345076 + 309 WP_001199743.1 CcdB family protein Toxin
LJF46_RS01640 (345482) 345482..345622 + 141 Protein_307 Arm DNA-binding domain-containing protein -
LJF46_RS01645 (345654) 345654..346787 - 1134 Protein_308 IS3 family transposase -
LJF46_RS01650 (347110) 347110..347640 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF46_RS01655 (347762) 347762..348502 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 343592..346695 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221670 WP_001199743.1 NZ_CP085806:344768-345076 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221670 NZ_CP117562:4882570-4882788 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221670 WP_001118105.1 NZ_CP085806:344526-344765 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221670 NZ_CP117562:4882170-4882544 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGATACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References