Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2242639..2243537 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MRA_RS10520 Protein ID WP_003410001.1
Coordinates 2242639..2243199 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MRA_RS10525 Protein ID WP_003410003.1
Coordinates 2243196..2243537 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS10490 2237808..2238461 - 654 WP_003409976.1 cutinase Cfp21 -
MRA_RS10495 2238576..2238806 + 231 WP_003409980.1 DUF167 domain-containing protein -
MRA_RS10500 2238891..2239802 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MRA_RS10505 2239911..2240510 + 600 WP_003409989.1 L-lysine exporter -
MRA_RS10510 2240926..2241354 + 429 WP_003409992.1 cellulose-binding protein -
MRA_RS10515 2241580..2242119 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MRA_RS10520 2242639..2243199 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MRA_RS10525 2243196..2243537 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MRA_RS10530 2243623..2243880 + 258 WP_003410006.1 hypothetical protein -
MRA_RS10535 2243781..2244116 - 336 WP_003410009.1 dehydrogenase -
MRA_RS10540 2244205..2244549 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MRA_RS10545 2244543..2244791 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MRA_RS10550 2244891..2247206 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MRA_RS10555 2247203..2247475 - 273 WP_003410017.1 DUF1490 family protein -
MRA_RS10560 2247528..2247884 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T22167 WP_003410001.1 NC_009525:c2243199-2242639 [Mycobacterium tuberculosis H37Ra]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T22167 NC_009525:c2243199-2242639 [Mycobacterium tuberculosis H37Ra]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT22167 WP_003410003.1 NC_009525:c2243537-2243196 [Mycobacterium tuberculosis H37Ra]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT22167 NC_009525:c2243537-2243196 [Mycobacterium tuberculosis H37Ra]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References