Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 303435..303951 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF46_RS01415 Protein ID WP_000220582.1
Coordinates 303667..303951 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF46_RS01410 Protein ID WP_000212724.1
Coordinates 303435..303677 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS01390 (298455) 298455..299588 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF46_RS01395 (299572) 299572..300690 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF46_RS01400 (300687) 300687..301427 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF46_RS01405 (301444) 301444..303357 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF46_RS01410 (303435) 303435..303677 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF46_RS01415 (303667) 303667..303951 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF46_RS01420 (303955) 303955..304419 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF46_RS01425 (304541) 304541..306679 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF46_RS01430 (307088) 307088..308740 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221669 WP_000220582.1 NZ_CP085806:303667-303951 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221669 NZ_CP117562:4297046-4297327 [Escherichia albertii]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCGCGTTTCGACATAGA
TGCGGCAGAACGTTTGTGGAAGCGCTTAAGAGCTTGCGTACTGCCGTTATCTGAGCATCCGTATTTATATCCACCAAGCG
ACAGAGTGCCTGGCTTGCGTGAGATTGTGGCCCACCCTAATTATATAATTCTTTACCGTGTGACCGCTTCAAGTATTGAA
ATTGTAAGTATCGTACACGCCAGACGCCAGTTTCCCAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221669 WP_000212724.1 NZ_CP085806:303435-303677 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221669 NZ_CP117562:4296854-4297042 [Escherichia albertii]
ATGAATACAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAGCGAGCCTTGCAGATCCGCGCCCAACAATTCCCCATGACGAGGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATACGCAAGGAACGGAGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References