Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 196274..197055 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF46_RS00840 Protein ID WP_000626100.1
Coordinates 196564..197055 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF46_RS00835 Protein ID WP_001110452.1
Coordinates 196274..196567 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS00800 (192321) 192321..193226 + 906 WP_001268200.1 YjiK family protein -
LJF46_RS00805 (193520) 193520..193651 - 132 Protein_147 hypothetical protein -
LJF46_RS00810 (193763) 193763..194011 - 249 Protein_148 Ig-like domain-containing protein -
LJF46_RS00815 (194010) 194010..194318 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF46_RS00820 (194311) 194311..194598 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF46_RS00825 (194595) 194595..195470 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF46_RS00830 (195736) 195736..195957 - 222 WP_001576552.1 hypothetical protein -
LJF46_RS00835 (196274) 196274..196567 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF46_RS00840 (196564) 196564..197055 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF46_RS00845 (197303) 197303..198055 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF46_RS00850 (198155) 198155..198232 - 78 Protein_156 porin family protein -
LJF46_RS00855 (198612) 198612..198686 + 75 Protein_157 helix-turn-helix domain-containing protein -
LJF46_RS00865 (198957) 198957..199532 - 576 WP_001188509.1 transcriptional regulator -
LJF46_RS00870 (199569) 199569..201272 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF46_RS00875 (201248) 201248..201595 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221668 WP_000626100.1 NZ_CP085806:196564-197055 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221668 NZ_CP117562:c3967676-3967521 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221668 WP_001110452.1 NZ_CP085806:196274-196567 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221668 NZ_CP117562:3967688-3967746 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References