Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4522028..4522809 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF48_RS22160 Protein ID WP_000626100.1
Coordinates 4522028..4522519 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF48_RS22165 Protein ID WP_001110452.1
Coordinates 4522516..4522809 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS22125 (4517488) 4517488..4517835 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF48_RS22130 (4517811) 4517811..4519514 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF48_RS22135 (4519551) 4519551..4520126 + 576 WP_001188509.1 transcriptional regulator -
LJF48_RS22145 (4520397) 4520397..4520471 - 75 Protein_4313 helix-turn-helix domain-containing protein -
LJF48_RS22150 (4520851) 4520851..4520928 + 78 Protein_4314 porin family protein -
LJF48_RS22155 (4521028) 4521028..4521780 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF48_RS22160 (4522028) 4522028..4522519 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF48_RS22165 (4522516) 4522516..4522809 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF48_RS22170 (4523126) 4523126..4523347 + 222 WP_001576552.1 hypothetical protein -
LJF48_RS22175 (4523613) 4523613..4524488 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF48_RS22180 (4524485) 4524485..4524772 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF48_RS22185 (4524765) 4524765..4525073 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF48_RS22190 (4525072) 4525072..4525320 + 249 Protein_4322 Ig-like domain-containing protein -
LJF48_RS22195 (4525432) 4525432..4525563 + 132 Protein_4323 hypothetical protein -
LJF48_RS22200 (4525857) 4525857..4526762 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221667 WP_000626100.1 NZ_CP085805:c4522519-4522028 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221667 NZ_CP117562:3754859-3755137 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACATTTGAGTTCGTCAAT
GGCAATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221667 WP_001110452.1 NZ_CP085805:c4522809-4522516 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221667 NZ_CP117562:3755137-3755421 [Escherichia albertii]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References