Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4374007..4374557 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF48_RS21365 Protein ID WP_001199743.1
Coordinates 4374007..4374315 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF48_RS21370 Protein ID WP_001118105.1
Coordinates 4374318..4374557 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS21345 (4370581) 4370581..4371321 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF48_RS21350 (4371443) 4371443..4371973 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF48_RS21355 (4372296) 4372296..4373429 + 1134 Protein_4162 IS3 family transposase -
LJF48_RS21360 (4373461) 4373461..4373601 - 141 Protein_4163 Arm DNA-binding domain-containing protein -
LJF48_RS21365 (4374007) 4374007..4374315 - 309 WP_001199743.1 CcdB family protein Toxin
LJF48_RS21370 (4374318) 4374318..4374557 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF48_RS21375 (4374666) 4374666..4374914 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF48_RS21380 (4374991) 4374991..4375536 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF48_RS21395 (4376293) 4376293..4377312 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF48_RS21400 (4377340) 4377340..4377870 - 531 WP_000896758.1 gluconokinase -
LJF48_RS21405 (4378087) 4378087..4379118 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4372388..4375491 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221665 WP_001199743.1 NZ_CP085805:c4374315-4374007 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221665 NZ_CP117562:3434134-3434237 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221665 WP_001118105.1 NZ_CP085805:c4374557-4374318 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221665 NZ_CP117562:c3434239-3434007 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References