Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4329746..4330322 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF48_RS21155 Protein ID WP_001131963.1
Coordinates 4330035..4330322 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF48_RS21150 Protein ID WP_000063142.1
Coordinates 4329746..4330048 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS21135 (4326256) 4326256..4328406 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LJF48_RS21140 (4328501) 4328501..4328704 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF48_RS21145 (4328715) 4328715..4329671 + 957 WP_000187843.1 GTPase -
LJF48_RS21150 (4329746) 4329746..4330048 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF48_RS21155 (4330035) 4330035..4330322 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF48_RS21160 (4330739) 4330739..4331995 + 1257 Protein_4123 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF48_RS21165 (4331989) 4331989..4332168 + 180 Protein_4124 DNA methyltransferase -
LJF48_RS21170 (4332158) 4332158..4333462 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221664 WP_001131963.1 NZ_CP085805:c4330322-4330035 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221664 NZ_CP117562:2288027-2288179 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221664 WP_000063142.1 NZ_CP085805:c4330048-4329746 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221664 NZ_CP117562:c2287982-2287934 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References