Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4365656..4366416 Replicon chromosome
Accession NZ_CP085804
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF49_RS21335 Protein ID WP_000533912.1
Coordinates 4365656..4366141 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF49_RS21340 Protein ID WP_000965886.1
Coordinates 4366129..4366416 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF49_RS21305 (4360728) 4360728..4361390 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF49_RS21310 (4361609) 4361609..4362583 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF49_RS21315 (4362633) 4362633..4363343 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF49_RS21320 (4363782) 4363782..4364072 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF49_RS21325 (4364360) 4364360..4364572 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF49_RS21330 (4364746) 4364746..4365285 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF49_RS21335 (4365656) 4365656..4366141 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF49_RS21340 (4366129) 4366129..4366416 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF49_RS21345 (4366594) 4366594..4367061 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF49_RS21350 (4367233) 4367233..4367631 - 399 Protein_4157 IS3 family transposase -
LJF49_RS21355 (4368021) 4368021..4370090 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF49_RS21360 (4370100) 4370100..4371011 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221641 WP_000533912.1 NZ_CP085804:c4366141-4365656 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221641 NZ_CP117558:2008192-2008295 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221641 WP_000965886.1 NZ_CP085804:c4366416-4366129 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221641 NZ_CP117558:c2008297-2008065 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCACGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References