Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4255701..4256287 Replicon chromosome
Accession NZ_CP085804
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag LJF49_RS20850 Protein ID WP_000174964.1
Coordinates 4255701..4256069 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag LJF49_RS20855 Protein ID WP_001522145.1
Coordinates 4256066..4256287 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF49_RS20830 (4251220) 4251220..4252290 - 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
LJF49_RS20835 (4252292) 4252292..4253137 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LJF49_RS20840 (4253134) 4253134..4254021 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LJF49_RS20845 (4254126) 4254126..4255442 - 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJF49_RS20850 (4255701) 4255701..4256069 - 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF49_RS20855 (4256066) 4256066..4256287 - 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF49_RS20860 (4256418) 4256418..4257131 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LJF49_RS20865 (4257133) 4257133..4257900 - 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LJF49_RS20870 (4257897) 4257897..4259174 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
LJF49_RS20875 (4259171) 4259171..4260097 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LJF49_RS20880 (4260157) 4260157..4261266 - 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4250483..4259174 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T221640 WP_000174964.1 NZ_CP085804:c4256069-4255701 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T221640 NZ_CP117558:1030533-1030685 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT221640 WP_001522145.1 NZ_CP085804:c4256287-4256066 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT221640 NZ_CP117558:c1030488-1030440 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4

Antitoxin

Source ID Structure

References