Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1122876..1123496 Replicon chromosome
Accession NZ_CP085804
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF49_RS05230 Protein ID WP_001280991.1
Coordinates 1122876..1123094 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF49_RS05235 Protein ID WP_000344807.1
Coordinates 1123122..1123496 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF49_RS05190 (1118099) 1118099..1118668 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF49_RS05195 (1118701) 1118701..1119090 - 390 WP_000961287.1 MGMT family protein -
LJF49_RS05205 (1119321) 1119321..1120871 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF49_RS05210 (1121096) 1121096..1121356 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF49_RS05215 (1121362) 1121362..1121502 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF49_RS05220 (1121558) 1121558..1122028 - 471 WP_000136183.1 YlaC family protein -
LJF49_RS05225 (1122146) 1122146..1122697 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF49_RS05230 (1122876) 1122876..1123094 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF49_RS05235 (1123122) 1123122..1123496 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF49_RS05240 (1123992) 1123992..1127141 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF49_RS05245 (1127164) 1127164..1128357 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221625 WP_001280991.1 NZ_CP085804:c1123094-1122876 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221625 NZ_CP117556:c2363158-2362877 [Escherichia albertii]
ATGCTGCCCATCTTATGGCTACCTTCTGCGCGTGATGATTTACGTCAGATCGTAGCCTATATTGCAAAAGAAAATCTCCA
TGCCGCACGTAGACTAAAAATTCGCATTGAGACATGTGTTTTAGCTTTATCCGAACATCCGTACTTATACCCATCAAGCG
ACAGAGTGTCTGGGTTGCGCGAGATTGTAGCTCACCCTAACTATATCATTCTGTACCGTGTGGCCACTTCAAGTATTGAA
ATTGTGAGCGTCGCCCACGCCAGACGCCAATTTCCTAGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221625 WP_000344807.1 NZ_CP085804:c1123496-1123122 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221625 NZ_CP117556:c2363349-2363158 [Escherichia albertii]
ATGAACACTGCTCTTTCGCCTATAGTTTCTGAATTTGAAACCATTGAGCAAGAAAACAGCTACAACGAATGGCTGCGTAC
AAAAGTAGCTGCAAGTCTTGCAGATCCGCGCCCTGCAATTCCCCATGATGAGGCAATGGCAGAAATAGAAAATCTCATTG
CCCAAATTTCTGCGACTAACGGGAGTGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References