Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4460059..4460819 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF50_RS21810 Protein ID WP_000533912.1
Coordinates 4460059..4460544 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF50_RS21815 Protein ID WP_000965886.1
Coordinates 4460532..4460819 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS21780 (4455131) 4455131..4455793 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF50_RS21785 (4456012) 4456012..4456986 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF50_RS21790 (4457036) 4457036..4457746 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF50_RS21795 (4458185) 4458185..4458475 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF50_RS21800 (4458763) 4458763..4458975 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF50_RS21805 (4459149) 4459149..4459688 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF50_RS21810 (4460059) 4460059..4460544 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF50_RS21815 (4460532) 4460532..4460819 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF50_RS21820 (4460997) 4460997..4461464 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF50_RS21825 (4461636) 4461636..4462034 - 399 Protein_4244 IS3 family transposase -
LJF50_RS21830 (4462424) 4462424..4464493 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF50_RS21835 (4464503) 4464503..4465414 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221615 WP_000533912.1 NZ_CP085803:c4460544-4460059 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221615 NZ_CP117556:388084-388239 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221615 WP_000965886.1 NZ_CP085803:c4460819-4460532 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221615 NZ_CP117556:c388072-388014 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References