Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 641803..642379 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF50_RS03060 Protein ID WP_001131963.1
Coordinates 641803..642090 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF50_RS03065 Protein ID WP_000063142.1
Coordinates 642077..642379 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS03045 (638662) 638662..639966 - 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -
LJF50_RS03050 (639956) 639956..640135 - 180 Protein_575 DNA methyltransferase -
LJF50_RS03055 (640129) 640129..641386 - 1258 Protein_576 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF50_RS03060 (641803) 641803..642090 + 288 WP_001131963.1 BrnT family toxin Toxin
LJF50_RS03065 (642077) 642077..642379 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF50_RS03070 (642454) 642454..643410 - 957 WP_000187843.1 GTPase -
LJF50_RS03075 (643421) 643421..643624 - 204 WP_000460616.1 YbdD/YjiX family protein -
LJF50_RS03080 (643719) 643719..645869 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221595 WP_001131963.1 NZ_CP085803:641803-642090 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221595 NZ_CP117518:c852400-851870 [Photobacterium sp. GSS17]
GTGAGCTGGTCAAAAACATTTGTTGAACTGGACAAGCATGTTCACGATCGAGCTTCATTTGACTGCGGTGAAGCTGAGTT
AAACACATTCATTCAGACTCAGGCATCAAAACATATGCAGGCAGGTATCAGCCGTACCATGGTGTTACCTGCCAGCCTGC
CGTTGCTCAATCAAAAATGGCCAATTTGCGCCTTCTATAGTGTCGCCCCGAGTTCTATTCGGCGTGAGACCTTGCCAGTA
TCATTGGCTAAAAAGCTACCTAATTATCCCATTCCGGTTTTCCTGCTTGCGCAATTGGCGGTTCACCGGGAATATCACGG
CCATGGTTTGGGTAAAGTTAGCCTGATTCGGGCGTTGAAATACCTGTGGGAAGTGAATGCCCATATGCGGGCTTATGCGA
TAGTGGTGGATTGCCTGACGCCTGCGGCGGAAGCGTTTTACACTAAGTACGGTTTTCAGGTGTTGTGTGATCACAATGGC
CGAACCCGAATGTTTATTCCGATGAAAACCGTTGGTCAGCTTTTTAGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221595 WP_000063142.1 NZ_CP085803:642077-642379 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221595 NZ_CP117518:c852666-852397 [Photobacterium sp. GSS17]
ATGGCAACAGCGCGTTTAGACCTGCGGTTAGACGAAGAGATTAAAGCCAAAGCAGAAAAAGCATCCGCTTTGCTGGGGTT
GAAGAGTCTGACCGAATATGTTGTCCGGCTGATGGATGAAGATGCAACGCAGGTTATTGCTCAACATGAAAGCATGACGG
TACAAAATGATGTATTTGATCGCTTTATGGACGCCTGTGATAAAGCAGAAGCGCCTAATCAGGCTCTGCGCGATGCCGCG
GCATTCACGGAAGAGAATGGATTCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References