Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 597571..598121 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF50_RS02850 Protein ID WP_001199743.1
Coordinates 597813..598121 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF50_RS02845 Protein ID WP_001118105.1
Coordinates 597571..597810 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS02810 (593010) 593010..594041 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF50_RS02815 (594258) 594258..594788 + 531 WP_000896758.1 gluconokinase -
LJF50_RS02820 (594816) 594816..595835 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF50_RS02835 (596592) 596592..597137 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF50_RS02840 (597214) 597214..597462 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF50_RS02845 (597571) 597571..597810 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF50_RS02850 (597813) 597813..598121 + 309 WP_001199743.1 CcdB family protein Toxin
LJF50_RS02855 (598527) 598527..598667 + 141 Protein_535 Arm DNA-binding domain-containing protein -
LJF50_RS02860 (598699) 598699..599832 - 1134 Protein_536 IS3 family transposase -
LJF50_RS02865 (600155) 600155..600685 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF50_RS02870 (600807) 600807..601547 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF50_RS23020 (601564) 601564..602565 + 1002 WP_235784150.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 596637..599740 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221594 WP_001199743.1 NZ_CP085803:597813-598121 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221594 NZ_CP117512:c94966-94625 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221594 WP_001118105.1 NZ_CP085803:597571-597810 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221594 NZ_CP117512:c95196-94966 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References