Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 449313..450094 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF50_RS02055 Protein ID WP_000626100.1
Coordinates 449603..450094 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF50_RS02050 Protein ID WP_001110452.1
Coordinates 449313..449606 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS02015 (445358) 445358..446264 + 907 Protein_374 YjiK family protein -
LJF50_RS02020 (446558) 446558..446689 - 132 Protein_375 hypothetical protein -
LJF50_RS02025 (446801) 446801..447049 - 249 Protein_376 Ig-like domain-containing protein -
LJF50_RS02030 (447048) 447048..447356 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF50_RS02035 (447349) 447349..447636 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF50_RS02040 (447633) 447633..448508 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF50_RS02045 (448774) 448774..448992 - 219 WP_227793085.1 hypothetical protein -
LJF50_RS02050 (449313) 449313..449606 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF50_RS02055 (449603) 449603..450094 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF50_RS02060 (450343) 450343..451095 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF50_RS02065 (451195) 451195..451272 - 78 Protein_384 porin family protein -
LJF50_RS02070 (451652) 451652..451726 + 75 Protein_385 helix-turn-helix domain-containing protein -
LJF50_RS02080 (451997) 451997..452572 - 576 WP_001188509.1 transcriptional regulator -
LJF50_RS02085 (452609) 452609..454312 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF50_RS02090 (454288) 454288..454635 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221592 WP_000626100.1 NZ_CP085803:449603-450094 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221592 NZ_CP117511:2698364-2698507 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGAAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221592 WP_001110452.1 NZ_CP085803:449313-449606 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221592 NZ_CP117511:c2698701-2698439 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGGCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTTCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References